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This medication comes along with a affected person details leaflet. Read and observe these Directions diligently before you start making use of sildenafil and each time you will get a refill within your medicine. Request your physician In case you have any concerns.thirty minutter til one time, Adult men det forutsetter at du er seksuelt stimulert. Ereksjonen vil ikke vare lengre enn normalt, og forsvinner som vanlig etter utløsning eller hvis guy ikke lenger er seksuelt stimulert.
Effects of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (slight route). As a result, inhibitors of those isoenzymes could decrease sildenafil clearance and inducers of these isoenzymes may well boost sildenafil clearance.
Ideal experiments haven't been executed on the connection of age to the results of sildenafil in children young than one yr of age. Protection and efficacy haven't been founded.
Denne medisinen skal kun brukes av menn. Dette fordi det foreløpig ikke foreligger nok forskningsresultater om hvordan potenspiller virker på kvinner og hvilke bivirkninger som kan forekomme.
Sildenafil is often a strong and selective inhibitor of cGMP-unique phosphodiesterase type five (PDE5), which is liable for degradation of cGMP while in the corpus cavernosum. The molecular construction of sildenafil is similar to that of cGMP and functions for a competitive binding agent of PDE5 within the corpus cavernosum, causing far more cGMP and increased penile response to sexual stimulation.
Som med al impotensmedicin er det meget vigtigt at tage den rigtige dosis. read more Den korrekte dosis afhænger af din helbredstilstand.
Following both oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (somewhere around eighty% of administered oral dose) and to a lesser extent while in the urine (approximately 13% on the administered oral dose).
Other Unwanted effects not mentioned may additionally occur in some patients. When you discover almost every other consequences, Examine with your Health care Expert.
The AUC of the active metabolite, N-desmethyl sildenafil, was amplified sixty two% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These results around the metabolite are certainly not envisioned to generally be of medical consequence.
In deciding to work with a medicine, the hazards of getting the medicine must be weighed in opposition to The nice it will eventually do. This is a choice both you and your health practitioner will make. For this medicine, the next ought to be viewed as:
Alpha-blockers are sometimes prescribed for prostate complications or significant blood pressure. In certain sufferers, using VIAGRA with alpha-blockers can result in a drop in blood pressure or to fainting.
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i.d.) resulted in the 63% lower of sildenafil AUC plus a 55% reduce in sildenafil Cmax . Concomitant administration of powerful CYP3A4 inducers, like rifampin, is predicted to bring about larger decreases in plasma levels of sildenafil.